Are membrane proteins ?inside-out? proteins?
نویسندگان
چکیده
منابع مشابه
Are membrane proteins "inside-out" proteins?
One of the central paradigms of structural biology is that membrane proteins are "inside-out" proteins, in that they have a core of polar residues surrounded by apolar residues. This is the reverse of the characteristics found in water-soluble proteins. We have decided to test this paradigm, now that sufficient numbers of transmembrane alpha-helical structures are accessible to statistical anal...
متن کاملTurning an opinion inside-out: Rees and Eisenberg's commentary (Proteins 2000;38:121-122) on "Are membrane proteins 'inside-out' proteins?" (Proteins 1999;36:135-143).
In any scientific discussion it is paramount to recognize what is agreed upon and what are the areas of contention. We are happy to conclude that Rees and Eisenberg in their recent commentary agree with us that membrane proteins are not “inside-out” proteins. They also concede that their original article, describing the use of the hydrophobic moments to model and understand membrane protein str...
متن کاملHow many membrane proteins are there?
One of the basic issues that arises in functional genomics is the ability to predict the subcellular location of proteins that are deduced from gene and genome sequencing. In particular, one would like to be able to readily specify those proteins that are soluble and those that are inserted in a membrane. Traditional methods of distinguishing between these two locations have relied on extensive...
متن کاملSorting out mitochondria| proteins
The understanding of how proteins are translocated across lipid bilayers is a fundamental question in organelle biogenesis. Considerable progress has been made in the field of mitochondrial protein topogenesis over the last few years (for recent reviews see Refs 1-6). Recent developments were discussed at a meeting* that focused on three aspects of mitochondrial biogenesis: the identification a...
متن کاملKicking out antiviral proteins
hen your gut tells you to run, it is wise to listen. Em-bryonic neural precursor cells do just that, according to De Bellard et al. (page 269), who identify the basis of an avoidance mechanism for migrating neural crest cells. Groups of embryonic neural precursors take separate paths on their way to forming the peripheral nervous system. Vagal cells, which emerge from the neck region, migrate l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1999
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(19990701)36:1<135::aid-prot11>3.0.co;2-i